Subacute Cutaneous Lupus Erythematosus

The term "subacute cutaneous lupus erythematosus" was coined in 1977 by Gilliam (Gilliam 1977) and further characterized by Sontheimer et al. (Sontheimer et al. 1979) in 1979. The authors introduced a previously undescribed variant of LE with skin lesions at the neck, shoulders, upper thorax, and arms. Clinically, recurrent annular polycyclic or papulosquamous lesions involve the upper trunk, extensor regions of the arms, and face and neck region.

The histopathologic features of SCLE are almost identical to those of DLE (Fig. 21.2). In individual cases, in particular in early lesions, differentiation by histopathologic features alone may be difficult or impossible. However, usually in SCLE there are more prominent changes at the dermoepidermal interface such as hydropic degeneration of the basal epithelial layer. Forming clefts or vesicles, epidermal atrophy, and dermal edema may be also more prominent as in DLE, and there may be extravasation of erythrocytes and dermal fibrin deposits. Apoptotic keratinocytes (Civatte bodies) in the epidermis may be numerous. In addition,the lymphocytic infiltrate is more confined to the upper dermis and bandlike compared with DLE.

Compared with DLE, SCLE has less hyperkeratosis, atrophy of pilosebaceous units, follicular plugging, and thickening of the basal layer (Bangert et al. 1984, Jerdan et al. 1990). The lupus band test result is positive in approximately 60% of cases.

Fig. 21.2A-C. Subacute cutaneous lupus erythematosus.

B Hydropic degeneration of the basal layer and apoptotic keratinocytes in the epidermis. C Mucin deposition in the dermis

Fig. 21.2A-C. Subacute cutaneous lupus erythematosus.

B Hydropic degeneration of the basal layer and apoptotic keratinocytes in the epidermis. C Mucin deposition in the dermis

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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