Sulfonamides and Sulfasalazine

The first report of drug-induced lupus involved a sulfonamide (Hoffman 1945), and yet the incidence of sulfonamide-induced lupus is very low. Sulfasalazine is associated with induction of a lupus-like syndrome, probably because it is metabolized to a sul-fonamide and another aromatic amine. Consistent with this hypothesis is the observation that the slow acetylator genotype is a very strong risk factor for sulfasalazine-induced lupus (Laversuch et al. 1995, Gunnarsson et al. 1997). Such an association is usually related to metabolism of aromatic amines, but the parent drug is not an aromatic amine. Renal disease seems to be common in sulfasalazine-induced lupus (Gunnarsson et al. 1997).

Was this article helpful?

0 0
Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

Get My Free Ebook

Post a comment