Tazarotene

The topical retinoid tazarotene is a member of a novel, conformationally rigid non-isomerizable class of retinoids, the acetylenic retinoids. It is hypothesized that the ability to adopt different shapes enables these retinoids to interact indiscriminately with many of the retinoid acid receptors and to activate multiple retinoid pathways. This receptor-selective topical retinoid decreases inflammation as well as abnormal differentiation and hyperproliferation of keratinocytes. Therefore, tazarotene successfully was introduced for the treatment of psoriasis (Chandraratna 1997). In one patient resistant to conventional therapies, topical tazarotene was used to treat hyper-keratotic lesions of DLE (Edwards and Burke 1999). A daily dose of 0.05% tazarotene gel was applied, and within several weeks facial lesions cleared, and the patient remained disease free for several months without experiencing any therapy-related side effects.

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