Patients with gallbladder and biliary disease may present with complaints of the right upper quadrant or mid-epigastric pain, fever, jaundice, pruritis, nausea, vomiting, or may be asymptomatic with only laboratory abnormalities. Technological advances in ultrasound (US), multidetector computed tomography (MDCT), and magnetic resonance imaging (MRI) have greatly improved the noninvasive evaluation of patients with signs and symptoms of gallbladder and biliary disease. In many instances, noninvasive imaging establishes the diagnosis prior to endoscopic or surgical intervention. The differential diagnosis for these patients is broad and includes infectious, noninfectious inflammatory, neoplastic, and congenital disorders of the liver, gallbladder, and bile ducts. This course uses a patterned approach to differential diagnosis to discuss and review pathologic processes that affect the gallbladder and bile ducts.

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