Biography

Karl B Thor, PhD, formed Urogenix, Inc., as a subsidiary of Astellas Pharmaceuticals, Inc., in March of 2007 and holds the position of vice-president of research. In addition, Dr Thor holds Adjunct Research Associate Professor positions in the Department of Surgery/Division of Urology and the Department of Obstetrics and Gynecology at Duke University Medical Center in Durham, North Carolina. He is Co-director of the Laboratory of Neurourology at the Veterans Affairs Medical Center, Surgical Research Services, also in Durham. The Laboratory of Neurourology receives grant support from the NIH, Veterans Administration, and Christopher Reeves Foundation for studies of neural control of the lower urinary tract under pathological conditions including spinal cord injury.

Dr Thor received his PhD in Pharmacology from the University of Pittsburgh School of Medicine where he trained under William (Chet) de Groat, PhD and was supported by a PhARMA predoctoral fellowship. He held a National Research Service Award postdoctoral fellowship from the NIH at Uniformed Services University of the Health Sciences in Bethesda, Maryland, and was a Senior Staff Fellow in the Laboratory of Neurophysiology at the NIH. He joined Eli Lilly in the Neuroscience Division in 1990, where he discovered duloxetine (Yentreve) as a treatment for stress urinary incontinence. In 1998, he formed PPD GenuPro as a subsidiary of PPD Inc., where he discovered the clinical potential of dapoxetine as a therapy for premature ejaculation. These two drugs are the first agents to be submitted to regulatory agencies for their respective indications. In 2002, he founded Dynogen Pharmaceuticals Inc., a neurosci-ence-based drug discovery and development company targeting genitourinary and gastrointestinal diseases, where two clinical program for overactive bladder and two clinical programs for irritable bowel syndrome were initiated.

Dr Thor has published numerous articles and book chapters on CNS control of lower urinary tract function and holds several patents for methods of treating urinary bladder and sexual dysfunction. He is a member of the Urodynamics Society, the International Continence Society, and the Society for Neuroscience. He served as a member of the FDA-PhARMA Industry Guidelines for Urinary Incontinence Trials in 1998. He has served as a peer reviewer for the NIH on the Urology Special Emphasis Study Section, the National Institutes of Neurological Disorders and Stroke Neurology B Study Section, and the Small Business Initiative Review Study Section. He has served on the World Health Organization's International Consultation on Incontinence since its inception.

© 2007 Elsevier Ltd. All Rights Reserved Comprehensive Medicinal Chemistry II

No part of this publication may be reproduced, stored in any retrieval system or transmitted ISBN (set): 0-08-044513-6 in any form by any means electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers ISBN (Volume 8) 0-08-044521-7; pp. 123-135

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