Drug Induced Changes in Calcium Channel Function

Building upon previous findings, David Dooley and colleagues (Pfizer Ann Arbor) showed that gabapentin reduces calcium influx and neurotransmitter release from rat and human brain tissues.72-78 Alexander McKnight and YP Maneuf (Parke-Davis Cambridge) found that gabapentin reduced glutamate release in a manner suggesting relevance for analgesia.79,80 Electrophysiologists in Cambridge and at Aberdeen University in the UK demonstrated changes in calcium channel and synaptic function that were presumed to be caused by gabapentin action at the a2-S site.81-85 These findings together with SAR described in Sections 8.18.2.3-8.18.2.5 provided a strong circumstantial argument that binding at to the a2-S site was important to the pharmacology of gabapentin and pregabalin.

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Dealing With Back Pain

Dealing With Back Pain

Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.

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