Summary

Based on all the above observations lonafarnib was recommended for clinical studies, and presently it is in third phase of the trial in cancer patients.

References

2. Sliskovic, D. R.; Picard, J. A.; Krause, B. R. Prog. Med. Chem. 2002, 3, 121-171.

3. Schnitzer-Polokoff, R.; Compton, D.; Boykow, G.; Davis, H.; Burrier, R. Comp. Biochem. Physiol. 1991, 99, 665-670.

4. Burnett, D. A.; Caplen, M. A.; Davis, H. R., Jr.; Burrier, R. E.; Clader, J. W J. Med. Chem. 1994, 37, 1733-1736.

5. Clader, J. W; Burnett, D. A.; Caplen, M. A.; Domalski, M. S.; Dugar, S.; Vaccaro, W; Sher, R.; Browne, M. E.; Zhao, H.; Burrier, R. E. et al. J. Med. Chem. 1996, 39, 3684-3693.

6. Salisbury, B. G.; Davis, H. R.; Burrier, R. E.; Burnett, D. A.; Boykow, G.; Caplen, M. A.; Clemmons, A. L.; Compton, D. S.; Hoos, L. M.; McGregor, D. G. et al. Atherosclerosis 1995, 115, 45-63.

7. Van Heek, M.; France, C. F; Compton, D. S.; McLeod, R. L.; Yumibe, N. P; Alton, K. B.; Sybertz, E. J.; Davis, H. R., Jr. J. Pharmacol. Exp. Ther. 1997, 283, 157-163.

8. Rosenblum, S. B.; Huynh, T; Afonso, A.; Davis, H. R., Jr.; Yumibe, N.; Clader, J. W; Burnett, D. A. J. Med. Chem. 1998, 41, 973-980.

9. Thiruvengadam, T. K.; Fu, X.; Tann, C.-H.; Mcallister, T. L.; Chiu, J. S.; Colon, C. International Patent W00034240, June 15 2000.

10. Dujovne, C. A.; Ettinger, M. P; McNeer, J. F; Lipka, L. J.; LeBeaut, A. P; Suresh, R.; Yang, B. O.; veltri, E. P Am. J. Cardiol. 2002, 90, 1092-1097.

11. Davidson, M. H.; McGarry, T; Bettis, R.; Melani, L.; Lipka, L. J.; LeBeaut, A. P; Suresh, R.; Sun, S.; Veltri, E. P J. Am. Coll. Cardiol. 2002, 40, 2125-2134.

12. Gagne, C.; Bays, H. E.; Weiss, S. R.; Mata, P; Quinto, K.; Melino, M.; Cho, M.; Musliner, T. A.; Gumbiner, B. Am. J. Cardiol. 2002, 90, 1084-1091.

13. Ballantyne, C. M.; Houri, J.; Notarbartolo, A.; Melani, L.; Lipka, L. J.; Suresh, R.; Sun, S.; LeBeaut, A. P; Sager, P. T.; Veltri, E. P. Circulation

2003, 107, 2409-2415.

14. Altmann, S. W; Davis, H. R., Jr.; Zhu, Li-ji.; Yao, X.; Hoos, L. M.; Tetzloff, G.; Iyer, S.PN.; Maguire, M.; Golovko, A.; Zeng, M. et al. Science

2004, 303, 1201-1204.

15. Saksena, A. K.; Girijavallabhan, V G.; Lovey, R. G.; Pike, R. E.; Wang, H.; Liu, Y T; Pinto, P; Bennett, F; Jao, E.; Patel, N.; et al. In Anti-Infectives: Recent Advances in Chemistry and Structure Activity Relationships; Bentley, P. H.; O'Hanlon, P. J. Eds.; Royal Society of Chemistry: Cambridge, UK, 1997; pp 180-199.

16. Richardson, K. In Recent Advances in the Chemistry of Anti-infective Agents:; Bentley, P H.; Ponsford, R. Eds.; Royal Society of Chemistry: Cambridge, UK, 1993; Chapter 12, p 182

17. Street, S. D. A. In Recent Advances in Chemistry and Structure Activity Relationships; Bentley, P H.; Ponsford, R. Eds.; Royal Society of Chemistry: Cambridge, UK, 1997; pp 141-151.

18. De Beule, K. Int. J. Antimicrob. Agents 1996, 6, 175.

19. Girijavallabhan, V M.; Ganguly, A. K.; Saksena, A. K.; Cooper, A. B.; Lovey, R,; Rane, D. F; Pike, R. E.; Desai, J. A.; Jao, E. In Recent Advances in the Chemistry of Anti-infective Agents;, Bentley, P. H.; Ponsford, R. Eds.; Royal Society of Chemistry: Cambridge, UK, 1993; p 191.

20. Saksena, A. K.; Girijavallabhan, V. M.; Lovey, R. G.; Pike, R. E.; Desai, J.; Ganguly, A. K.; Hare, R. S.; Loebenberg, D.; Cacciapuoti, A.; Parmegiani, R. M. Bioorg. Med. Chem. Lett. 1994, 2023.

21. Saksena, A. K.; Girijavallabhan, V M.; Lovey, R. G.; Desai, J. D.; Pike, R. E.; Jao, E.; Wang, H.; Ganguly, A. K.; Loebenberg, D.; Hare, R. et al. Bioorg. Med. Chem. Lett. 1995, 5, 127-132.

22. Saksena, A. K.; Girijavallabhan, V M.; Wang, H.; Liu, Y T.; Pike, R. E.; Ganguly, A. K. Tetrahedron Lett. 1996, 37, 5657.

23. Ganguly, A. K.; Doll, R. J.; Girijavallabhan, V M. Curr. Med. Chem. 2001, 8, 1419-1436.

24. Njoroge, F G.; Taveras, A. G.; Kelly, J.; Remiszewski, S.; Mallams, A. K.; Wolin, R.; Afonso, A.; Cooper, A. B.; Rane, D. F; Liu, Y-T et al. J. Med. Chem. 1998, 41, 4890.

25. Britten, C. D.; Rowinsky, E.; Yao, S.-L.; Rosen, N.; Eckhardt, S. G.; Drengler, R.; Hammond, L.; Siu, L. L.; Smith, L. et al. Proc. Am. Soc. Clin. Oncol. 1999, 597.

26. Hunt, J. T Abstracts of the 219th American Chemistry Society National. Meeting, 2000.

27. Hudes, G. R.; Schol, J.; Baab, J.; Rogatko, A.; Bol, K.; Horak, I.; Langer, C.; Goldstein, L. J.; Szarka, C.; Meropl, N. J.; Weiner, L. Proc. Am. Sec. Clin. Oncol. 1999, 601.

29. Boyartchuk, V L.; Ashby, M. N.; Rine, J. Science 1997, 275, 1796.

30. Clarke, S. Annu. Rev. Biochem. 1996, 271, 11541.

31. Bishop, W R.; Bond, R.; Petrin, J.; Wang, L.; Patton, R.; Doll, R.; Njoroge, G.; Catino, J.; Schwartz, J.; Windsor, W et al. J. Biol. Chem. 1995, 270, 30611.

32. Njoroge, F G.; Doll, R. J.; Vibulbhan, B.; Alvarez, C. S.; Bishop, W R.; Petrin, J.; Kirschmeier, P; Carruthers, N. I.; Wong, J. K.; Albanese, M. M. et al. Bioorg. Med. Chem. 1997, 5, 101.

33. Strickland, C. L.; Weber, P C.; Windsor, W T.; Wu, Z.; Le, H. V; Albanese, M. M.; Alvarez, C. S.; Cesarz, D.; del Rosario, J.; Deskus, J. et al. J. Med. Chem. 1999, 42, 2125.

34. Mallams, A. K.; Njoroge, F G.; Doll, R. J.; Snow, M. E.; Kaminski, J. J.; Rossman, R. R.; Vilbulbhan, B.; Bishop, W R.; Kirschmeier, P.; Liu, M. et al. Bioorg. Med. Chem. 1997, 5, 93.

A K Ganguly was bom in India and educated partly in India and in England. He received his PhD degree from Imperial College, London under the supervision of Sir Derek Barton.

Prof Ganguly immigrated to the United States in 1967 and worked with Sir Derek at the Research Institute of Medicine and Chemistry, Cambridge, Massachusetts before joining the Schering-Plough Research Institute, Kenilworth, NJ in 1968 as a Senior Scientist. At Schering-Plough Research Institute he progressed to the position of Senior Vice President of Chemical Research in which capacity he directed all aspects of Chemical Research at the

Biography

institute. In September 1999 he joined Stevens Institute of Technology, Hoboken, NJ as a Distinguished Research Professor of Chemistry where he teaches Medicinal Chemistry and directs research programs for graduate students.

Prof Ganguly has made many significant contributions in drug discovery. He is associated with the discovery of Ezetimibe (Zetia), a cholesterol absorption inhibitor; Noxafil (Posaconazole), a potent antifungal and Lonafarnib (Sarasar), a highly selective farnesyl protein transferase inhibitor for the treatment of cancer. Prof Ganguly is also recognized for his many contribution toward synthesis of biologically active molecules and determining structures of complex oligosaccharide antibiotics such as Ziracin. Prof Ganguly has published 176 papers and is a coinventor of 80 patents. He has been a plenary lecturer at many international meetings and received several awards. In 2003, Prof Ganguly received the prestigious Hershberg award from the American Chemical Society for making important contributions in Medicinal Chemistry. In 2004, Prof Ganguly received Doctor of Engineering (Honoris Causa) from Stevens Institute of Technology and was also the recipient of the 'Life time achievement award in Chemical Sciences' from the Indian Chemical Society. Prof Ganguly remains as a consultant at Schering-Plough Research Institute.

© 2007 Elsevier Ltd. All Rights Reserved Comprehensive Medicinal Chemistry II

No part of this publication may be reproduced, stored in any retrieval system or transmitted ISBN (set): 0-08-044513-6 in any form by any means electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers ISBN (Volume 8) 0-08-044521-7; pp. 29-51

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