Materials And Methods

27.2.1 Lifelong Supplementation of Coenzyme Q10 In order to identify differences in survival and longevity, we followed all 150 male Sprague-Dawley rats and 86 male c57 B17 strain mice throughout their life spans. Both rats and mice were randomly assigned to a study group receiving 10 mg kg day of coenzyme Q10 or control group receiving a standard diet. Ubiquinone Q10 was mixed into the normal animal diet by using soybean oil as a vehicle. Soybean oil was also added to the control food. All the...

Other Diseases

Plasma levels of ubiquinol-10 have been measured in several other diseases and pathological conditions. Significantly lower values of plasma ubiquinol-10 (compared to controls), have been reported for adult respiratory distress syndrome56 and infant asphyxia.57 Both these conditions are related to highly increased oxidative stress. This implies that plasma ubiquinol-10 can be decreased as a result of a massive and acute oxidative stress when antioxidant defense systems of the body are overcome....

Coenzyme Q And Atherosclerosis

9.4.1 Levels of a-TOH and CoQ10H2 in Plasma of Patients with Cardiovascular Disease As CoQ10H2 is the first lipoprotein-associated antioxidant consumed when plasma is exposed to various oxidizing conditions, it has been proposed that the plasma coenzyme Q10 redox status i.e., CoQ10H2 (CoQ10H2 + CoQ10) may represent a useful diagnostic indicator for in vivo lipoprotein oxidation and oxidative stress.74 A number of studies have compared the levels of CoQ10H2 in the plasma of patients with...

Info

S. and Rubin, E., Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption, J. Biol. Chem., 256, 6090-6097, 1981. Casu, A., Cottalasso, D., Pronzato, M. A., Marinari, U. M., and Nanni, G., Phospholipids, vitamin A and ubiquinone of the Golgi apparatus subfractions from rat liver after acute ethanol intoxication, Exp. Pathol., 25, 251-255, 1984. Casu, A., Cottalasso, D., Pronzato, M. A., Rolla, C., Marinari, U. M., and Nanni, G., Investigation of...

References

Ernster, L. and Dallner, G., Biochemical, physiological and medical aspects of ubiquinone function, Biochim. Biophys. Acta, 1271, 195, 1995. 2. Linnane, A. W., Degli Esposti, M., Generowicz, M., Luff, A. R., and Nagley, P., The universality of bioenergetic diseases and amelioration with redox therapy, Biochim. Biophys. Acta, 1271, 191, 1995. Strijks, E., Kremer, H. P., and Horstink, M. W., Q10 therapy in patients with idiopathic Parkinson's disease, Mol. Aspects Med, 18, S237, 1997. Shults, C....

Coq As A Cardioprotective Drug

Coenzyme Q10 (CoQ) has long been utilized as a cardioprotective drug treating myocardial ischemic heart disease, heart failure, and cardiotoxic chemical intoxication. As a member of the mitochondrial electron transfer chain, CoQ is directly involved in energy transduction and aerobic ATP production it transports electrons in the respiratory chain and couples the respiratory chain to oxidative phosphorylation.1,2 In addition, CoQ is a powerful antioxidant not only within the mitochondria but...

Effects Of Dietary Supplementation Of Ubiquinone On Carcinogenesis

The results showing reduced levels of ubiquinone in HCCs are thus in concordance with data from experimental animal models and on human cancers. Increased levels of ubiquinone in preneoplastic foci may contribute to their increased resistance to oxidative stress. However, the reasons as to why these cells decrease their levels of ubiquinone during malignant transformation remain unclear. In light of these findings, reports of ubiquinone levels in blood from cancer patients is pertinent. Folkers...

The Solt And Farber Animal Model Of Chemical Hepatocarcinogenesis

When studying the effects of xenobiotics and antioxidants during liver carcinogenesis, experimental models have been created. One of the most commonly employed models for this purpose is the Solt and Farber model of chemical hepatocarcinogenesis,57 in which the effects of carcinogens or anticancer drugs can be studied sequentially during initiation, promotion, and progression respectively (Figure 23.3).53 In this animal model on rat liver, commonly known as the resistant hepa-tocyte model,3...