Iron Overload Depletes Hepatic Antioxidants

Iron has been used as a model substance in the studies of oxidative liver damage, since iron is known to increase the production of free radicals and enhance oxidative stress.24,25 In humans, the most common diseases with iron overload are genetic hemochromatosis and transfusional iron overload. Genetic hemochromatosis is an inherited disorder of iron metabolism in which excess iron is absorbed via the gut and deposited in parenchymal organs, predominantly the liver.26,27 With time, deposition...

Other Diseases

Plasma levels of ubiquinol-10 have been measured in several other diseases and pathological conditions. Significantly lower values of plasma ubiquinol-10 (compared to controls), have been reported for adult respiratory distress syndrome56 and infant asphyxia.57 Both these conditions are related to highly increased oxidative stress. This implies that plasma ubiquinol-10 can be decreased as a result of a massive and acute oxidative stress when antioxidant defense systems of the body are overcome....

Coenzyme Q And Atherosclerosis

9.4.1 Levels of a-TOH and CoQ10H2 in Plasma of Patients with Cardiovascular Disease As CoQ10H2 is the first lipoprotein-associated antioxidant consumed when plasma is exposed to various oxidizing conditions, it has been proposed that the plasma coenzyme Q10 redox status i.e., CoQ10H2 (CoQ10H2 + CoQ10) may represent a useful diagnostic indicator for in vivo lipoprotein oxidation and oxidative stress.74 A number of studies have compared the levels of CoQ10H2 in the plasma of patients with...

Johan Bernard Ubbink Contents

18.1 Introduction Oxidative Stress in Cardiovascular 18.2 Measurement of Oxidative 18.3 Evidence that the CoQ10H2 CoQ10 Ratio Reflects Lipoprotein Exposure to Oxidative 18.4 CoQ10H2 CoQ10 Ratio in Patients with Cardiovascular 18.5 Concluding 18.1 INTRODUCTION OXIDATIVE STRESS IN CARDIOVASCULAR DISEASE Lipid peroxidation is a fundamental process in atherogenesis.1,2 LDL particles are modified by free radical mediated reactions, causing lipid peroxidation and thus oxidative damage to LDL.1,2 Free...

Coq As A Cardioprotective Drug

Coenzyme Q10 (CoQ) has long been utilized as a cardioprotective drug treating myocardial ischemic heart disease, heart failure, and cardiotoxic chemical intoxication. As a member of the mitochondrial electron transfer chain, CoQ is directly involved in energy transduction and aerobic ATP production it transports electrons in the respiratory chain and couples the respiratory chain to oxidative phosphorylation.1,2 In addition, CoQ is a powerful antioxidant not only within the mitochondria but...

Effects Of Dietary Supplementation Of Ubiquinone On Carcinogenesis

The results showing reduced levels of ubiquinone in HCCs are thus in concordance with data from experimental animal models and on human cancers. Increased levels of ubiquinone in preneoplastic foci may contribute to their increased resistance to oxidative stress. However, the reasons as to why these cells decrease their levels of ubiquinone during malignant transformation remain unclear. In light of these findings, reports of ubiquinone levels in blood from cancer patients is pertinent. Folkers...

Info

E., The participation of coenzyme Q in free radical production and antioxidation, Free Radic. Biol. Med., 8, 545-565, 1990. Frei, B., Kim, M., and Ames, B. N., Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations, Proc. Natl. Acad. Sci. U.S.A., 87, 4879-4883, 1990. Yamamoto, Y., Komura, E., and Niki, E., Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome, J. Nutr. Sci. Vitaminol., 36, 505-511, 1990. Mukai, K., Kikuchi, S.,...