Effects Of Dietary Supplementation Of Ubiquinone On Carcinogenesis

The results showing reduced levels of ubiquinone in HCCs are thus in concordance with data from experimental animal models and on human cancers. Increased levels of ubiquinone in preneoplastic foci may contribute to their increased resistance to oxidative stress. However, the reasons as to why these cells decrease their levels of ubiquinone during malignant transformation remain unclear. In light of these findings, reports of ubiquinone levels in blood from cancer patients is pertinent. Folkers et al. reported decreased blood levels of coenzyme Q10 in patients with myeloma and breast cancer.77 In this study, the fractions of cancer patients with blood levels of coenzyme Q10 below 0.5 ^g/ml (breast cancer) and 0.7 ¡xg/ml (myeloma patients) were significantly increased compared with ordinary people. However, 49% of the ordinary people had levels below 0.8 ^ag/ml, indicating a wide range of values in all groups studied. Only myeloma patients had significantly reduced mean blood levels of coenzyme Q10 as compared with ordinary people.77 Reports studying the effects of dietary supplementation with nutritional antioxidants, essential fatty acids, and coenzyme Q10 on patients with "high-risk" breast cancer indicate a tumor-suppressive effect by this regimen.78 However, these findings are not supported by other studies in which two months of supplementation with antiox-idants, including ubiquinone-10, did not result in significant changes in the urinary excretion rate of 8-oxo-dG, although the plasma antioxidant concentrations were increased.79

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