References

Abt M, Lim Y-B, Sacks J, Xie M, Young SS. A sequential approach for identifying lead compounds in large chemical databases. Stat Sci 2001 16 154-68. 2. Dorfman L. The amazing story of Superman-Red and Superman-Blue. In Superman 162. DC Comics, 1963. 3. Goldratt EM, Schragenheim E, Ptak CA. Necessary but not sufficient. North River Press, 2000. 4. FDA. Innovation or Stagnation Challenge and Opportunity on the Critical Path to New Medical Products. March 16, 2004. http www.fda.gov oc initiatives...

The Web Interface

In Section 31.4, we explained the data structure that we use to represent and build an UltraLink. Now, we outline how the Web interface of the KSP assembles the information to user-friendly dialogs. Figure 31.2A shows the results of a simple query sent to the KSP (list of ranked documents records) and how the extracted concepts are displayed. The concepts are grouped into color-coded types (Figure 31.2B, keywords). The recognized entities are presented as a set of clickable concepts highlighted...

Power And Predictive Biosimulation 3241 Petaflop and Grid Computing

The simulation of events as complicated as the interaction of biological systems such as protein folding, cells, organs, and whole organisms requires both elegant algorithms and enormous computer power 9 . This chapter will not describe the intricacies of grid and supercomputing except to say that a new generation of petaflop computers will enable Pharma to begin large-scale biomolecular simulations. To give an example, the computational effort required to study protein folding is enormous....

Data Utilization Extraction And Standards

Currently the NIH road map is driving a systems biology agenda, with academia and government trying to facilitate this. Systems biology at the moment is significantly dominated by genomic experimental data and networks, and it is perhaps telling that the NIH and FDA have access to virtually all commercially available network-building software and databases. The FDA has released a guidance for industry on the use of pharmacogenomics data for drug safety evaluation and is actively working to...

Risk Infection Care Plan

Eisenberg JM, Freund D, Glick H, et al. Clinical economics education in the International Clinical Epidemiology Network. INCLEN Economics Faculty. J Clin Epidemiol 1989 42 689-95. 2. Weinstein MC, Stason WB. Foundations of cost-effectiveness analysis for health and medical practices. N Engl J Med 1977 296 716-21. 3. Pare D, Freed M. Clinical practice guidelines for quality patient outcomes. Nurs Clin North Am 1995 30 183-96. 4. Winslow R. Study compares role of doctors in cardiac cases. Wall...

Introduction

Anyone who has worked for some time in the pharmaceutical industry has a story of how a successful drug was developed after a fortuitous coffee machine encounter between two or more scientists, or how a problem was not discovered until late-stage development because an important piece of information was missed. A tragic example described in the literature tells of a 24-year-old woman who died in 2001 after participating in a research study involving administration of hexamethonium bromide by...

Systems Biology Commercial Applications

A recent review has described the numerous commercial concerns that are involved in systems biology by providing either software or services 24 . Large, curated interaction databases combined with powerful analytical and network building tools are commercially available from companies like GeneGo Inc. MetaCore , Ariadne Genomics Inc. Pathway Studio , Ingenuity Inc. Pathways Analysis , and Jubilant Biosys PathArt that cover human metabolism, regulation, and signaling Table 6.1 . Currently there...

Bioinformatics And Vaccine Discovery

Immunoinformatics is a newly emergent subdiscipline within the informatic sciences that deals specifically with the unique problems of the immune system. Like bioinformatics, immunoinformatics complements, but never replaces, laboratory experimentation. It allows researchers to address, in a systematic manner, the most important questions in the still highly empirical world of immunology and vaccine discovery. The first vaccine was discovered by Edward Jenner in 1796, when he used cowpox, a...

Computers As Data Analysis And Data Management Tools In Preclinical Development

2.2 Chromatographic Data Systems CDS 2.2.2 The Emergence and Evolution of CDS 2.3 Laboratory Information Management Systems LIMS 2.3.1 LIMS Hardware and Architectures 2.4 Text Information Management Systems TIMS 2.4.1 Documentation Requirements in Preclinical Development Computer Applications in Pharmaceutical Research and Development, Edited by Sean Ekins. ISBN 0-471-73779-8 Copyright 2006 John Wiley amp Sons, Inc. Scientists from many different disciplines participate in pharmaceutical...

Contributors

Mazen Abdellatif, Hines VA Cooperative Studies Program Coordinating Center 151K , P.O. Box 5000, 5th Ave. and Roosevelt Rd. Bldg. 1, Rm. B240, Hines, IL 60141-5000, USA. mazen.abdellatif med.va.gov . Heather Ahlborn, IBM Business Consulting Services, Pharma and Life Sciences, Armonk, NY 10504, USA. ahlborn us.ibm.com . Konstantin V. Balakin, ChemDiv, Inc. 11558 Sorrento Valley Rd., Ste. 5, San Diego, CA 92121, USA. kvb chemdiv.com . Kenneth Banks, Global Analytical Development, Johnson amp...