Acidbase Disorder Common Causes

Examples of mixed Respiratory acidosis and metabolic alkalosis: chronic obstructive pulmonary dis-

dlsorders ease (COPD) produces chronically elevated Paco2 levels and high HCO3

levels as a compensatory mechanism. If the chronically elevated Paco2 is rapidly decreased, as it would be with aggressive mechanical ventilation, HCO3 levels remain elevated, causing metabolic alkalosis Respiratory alkalosis and metabolic acidosis: salicylate ingestion directly stimulates the respiratory center, resulting in an increased rate and depth of breathing; ingestion of large amounts of salicylates can also produce metabolic acidosis; respiratory alkalosis results from the "blowing off" of CO2

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