Causes

Although the causes of migraine headache are uncertain, a commonly held theory is that early vasoconstriction and subsequent vasodilation occur because of the release of biologically active amines such as serotonin, norepinephrine, and epinephrine. These amines are powerful vasoconstrictors, and after their release, degradation and depletion may lead to vasodilation and the headache syndrome. Another theory suggests that neurokinin, a biologic substance similar to bradykinin, may be responsible for the inflammatory response.

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