The many causes of hypophosphatemia include dietary changes, GI abnormalities, drug interactions, hormonal changes, and cellular changes. Changes in the diet as a result of malnutrition or alcoholism can significantly reduce the serum phosphorus levels. Inadequate amounts of phosphorus in total parental nutrition may also lead to hypophosphatemia. GI problems that result in a phosphorus deficit include vomiting, chronic diarrhea, and intestinal malabsorption because of vitamin D deficiency. Two types of medications that most commonly decrease serum phosphorus are aluminum-containing antacids and diuretics. Aluminum binds with phosphorus in the GI tract, and most diuretics promote urinary excretion of phosphorus. Infusion of glucose also leads to phosphate depletion, as do increased levels of PTH, which increase the urinary excretion of phosphorus. Cellular changes in several disorders, such as diabetic ketoacidosis (DKA), burns, and acid-base disorders, lead to hypophosphatemia.

Hypophosphatemia DRG Category:

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