Causes

Several conditions contribute to SIADH. Central nervous system (CNS) responses to fear, pain, psychoses, and acute distress are known to increase the rate of ADH secretion by the posterior pituitary gland. Physiological conditions that increase intracranial pressure, such as acute CNS infections, brain trauma, anoxic brain death, cerebrovascular accident, and brain surgery, may lead to SIADH. Other conditions associated with SIADH include peripheral neuropathy, delirium tremens, and Addison's disease and also certain medications such as analgesics, anesthetics, thiazide diuretics, and nicotine. Some tumors have been associated with ADH production, such as small cell carcinoma of the lungs, pancreatic cancer, prostate cancer, and Hodgkin's disease. Positive pressure ventilation can also lead to SIADH in normov-olemic individuals.

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