Causes

Graves' disease has an autoimmune derivation and is caused by circulating anti-TSH autoanti-bodies that displace TSH from the thyroid receptors and mimic TSH by activating the TSH receptor to release additional thyroid hormones. Graves' disease is also associated with Hashimoto's disease, a chronic inflammation of the thyroid gland that usually causes hypothyroidism but can also cause symptoms similar to those of Graves' disease.

Thyrotoxicosis has several different pathophysiological causes, including autoimmune disease, functioning thyroid adenoma, and infection.

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