The cause of colorectal cancer is largely unknown; however, there is much evidence to suggest that incidence increases with age. Risk factors include a family history of colorectal cancer and a personal history of past colorectal cancer, ulcerative colitis, Crohn's disease, or adenomatous colon polyps. Persons with familial polyposis coli, an inherited disease that is characterized by multiple (>100) adenomatous polyps, possess a risk for colorectal cancer that approaches 100% by age 40. Other risk factors include obesity, diabetes mellitus, alcohol usage, night shift work, and physical inactivity.

It has been strongly suggested that diets high in fat and refined carbohydrates play a role in the development of colorectal cancer. High-fat content results in increased amounts of fecal bile acid. It is hypothesized that intestinal bacteria react with the bile salts and facilitate carcinogenic changes. In addition, fat and refined carbohydrates decrease the transit of food through the gastrointestinal (GI) tract and increase the exposure of the GI mucosa to carcinogenic substances that may be present. Recent research indicates that aspirin, cytochrome C oxidase (COX)-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs), folate, calcium, and estrogen replacement therapy have a potential chemoprotective effect and may prevent colorectal cancer.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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