Causes

Etiologic factors are unclear, but most experts identify an immunologic origin for the disease. AGN may occur as an isolated (primary) disorder, as a disorder associated with an infectious disease, or as a secondary disorder. Primary AGN occurs in mesangiocapillary glomerulonephritis and in IgA nephropathy. Infection-associated AGN follows an infection such as group A beta-hemolytic streptococcus (GABHS) infection. Nonstreptococcal postinfectious glomerulonephritis may occur after an attack of infective endocarditis, sepsis, pneumococcal pneumonia, viral hepatitis, mumps, or measles. RPGN is associated with vasculitie, SLE, Goodpasture's syndrome, and IgA nephropathy.

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