Dbridement Except for Skin Ulcer or Cellulitis with CC

Skin cancer is the most common malignancy in the United States, accounting for over 50% of all diagnosed cancers. The majority of skin cancers (more than 90%) are classified as non-melanoma skin cancers (NMSCs) of which there are two types: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Approximately 75% of skin cancers are BCC; SCC is the next most common skin cancer, followed in frequency by melanoma. More than 1.3 million cases of NMSC are diagnosed annually. Other, less frequently occurring skin cancers include skin adnexal tumors, Kaposi's sarcoma, various types of sarcomas, Merkel cell carcinoma, and cutaneous lymphoma, all of which together account for fewer than 1% of NMSCs.

BCC is a slow-growing, nonmetastasizing neoplasm of the nonkeratinizing cells of the basal layer of the epidermis, that extends wide and deep if left untreated. If distant metastasis does occur to the bone, brain, lung, and liver, the prognosis is grave. BCC is most frequently found on the head, neck, and on skin that has hair. There are two types of BCC. The nodular ulcerative BCC is a nodulocystic structure that begins as a small, flesh-colored, smooth nodule that enlarges over time. A central depression forms that progressess to an ulcer surrounded by a waxy border. The superficial BCC is often seen on the chest or back and begins as a flat, nonpalpable, erythematous plaque that enlarges and becomes red and scaly with nodular borders. Although BCC can be treated effectively, it is not uncommon for it to return after treatment. From 35% to 50% of people diagnosed with one BCC will develop a new skin cancer within 5 years of the first diagnosis.

SCC leads to an invasive tumor that can metastasize to the lymph nodes and visceral organs. SCC, which constitutes 20% of all skin cancers, is characterized by lesions on the squamous epithelium of the skin and mucous membranes. SCC appears as a red, scaling, keratotic, slightly elevated lesion with an irregular border, usually with a shallow chronic ulcer. The risk of metastasis is associated with the size and penetration of the tumor, the tumor morphology, and the causative factors. Complications of NMSCs include disfigurement of facial structures and metastasis to other tissues and organs.

Because occurrence of NMSC is not reported, incidence can only be estimated. It is suspected that more than 1 million cases of BCC occur each year, and 1000 to 2000 deaths occur from BCC. The 5-year survival rate for patients with BCC is greater than 99%; although BCCs rarely spread to lymph nodes or other organs, those patients who do have metastasized BCC have a 5-year survival rate of only 10%. The overall 5-year survival rate for patients with SCC is more than 95%; for patients with spread of SCC to lymph nodes or other organs, the 5-year survival rate is 25%.

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