Genetic Considerations

Mutations in a variety of genes have been associated with the production of familial ventricular dysrhythmias. The long QT syndrome (caused by mutations in potassium, sodium channels and an anchoring protein) can result in a polymorphic VT called torsades de pointes. Long QT can be passed as an autosomal dominant (Romano-Ward) or recessive (Jervell and Lange-Neilsen) trait. Brugada syndrome is caused by a sodium channel mutation and results in episodes of VF and sudden cardiac death. Catecholaminergic polymorphic VT results from defects in calcium or potassium channel genes .

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