Genetic Considerations

Low blood sodium is a feature of several heritable endocrine imbalances. Pseudohypoaldostero-nism type 1 (PH 1) is a salt-wasting disorder that can be transmitted in either an autosomal

492 Hyponatremia dominant or an autosomal recessive pattern. Kidney, colon, and sweat and salivary gland resistance to aldosterone is a feature of the autosomal recessively transmitted form, while the autosomal dominantly transmitted form is characterized primarily by renal resistance to aldosterone.

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