Genetic Considerations

Hemophilia is an X-linked recessive condition. Both factor VIII and factor IX genes are located on the X chromosome; therefore, hemophilia affects males almost exclusively. Daughters of men with hemophilia are obligate carriers, but sons of affected men are normal. When a carrier woman has a son, his risk of disease is 50% and each of her daughters has a 50% risk of also being a carrier. Female offspring have a 50% chance of being affected with hemophilia if an affected male mates with a carrier female.

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