Genetic Considerations

Many MI risk factors such as diabetes mellitus, cholesterol levels, and hypertension have genetic contributions. However, family history is an independent risk factor indicating that there are susceptibility genes in addition to those involved in producing identified risk factors are probably involved. Many candidate genes have been investigated. Polymorphisms in the connexin 37 gene, the plasminogen-activator inhibitor type 1 gene and the stromelysin-1 gene have been associated with increased risk, but clear descriptions of genetic contributions remain elusive.

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