Genetic Considerations

A polymorphism in the interferon-gamma receptor-1 gene (IFNGR1) is associated with an increased likelihood of H. pylori infection. Another susceptibility factor is a variation in the Lewis (b) blood group antigen an epithelial receptor for H. pylori. Autosomal dominant transmission of elevated serum pepsinogen I (PG I) levels has been seen in families with a history of duodenal ulcer. Peptic ulcer is also seen as a component of other genetic conditions including Zollinger-Ellison syndrome.

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