Genetic Considerations

The ways in which genes influence behavior are complex and definitive studies have proved elusive. Finding genetic causes of susceptibility to substance abuse has been difficult. Genes associated with predisposition to dependence and risky behaviors include those encoding the dopamine D4 receptor, phosphodiesterease 1B, the AMPA receptor subunit GluRl, 5HT1B receptor, protein kinase C, and the transcription factor FosB. Variations in monoamine oxidase B (MAOB) influence a behavioral response to novelty. A decreased expression of the gene encoding the 5-HTT transporter may also be associated with an increased risk for substance use disorders.

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