Genetic Considerations

SAH appears to cluster in families independent of environmental factors as does the propensity to have vasospasm following surgery. Patients with APOE-E4 allele have demonstrated poorer outcomes after aneurysmal SAH than those with other variants of this gene even though an association between APOE and incidence of the SAH has not been well documented. The autosomal dominantly transmitted disorder, polycystic kidney disease (ADPKD), has also been associated with an increased incidence of SAH.

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