Genetic Considerations

See Adrenal Insufficiency.

GENDER, ETHNIC/RACIAL, AND LIFE SPAN CONSIDERATIONS

Acute adrenal crisis may occur at any age, without regard to gender, and may be associated with developmental or genetic abnormalities. Ethnicity and race have no known effects on the risk for acute adrenal crisis. In children, the most common cause of acute adrenal crisis is an overwhelming infection with Pseudomonas or meningococcal meningitis (also known as Water-house-Friderichsen syndrome). In adults, acute adrenal crisis is more commonly associated with hemorrhagic destruction because of anticoagulant therapy or aggravation of adrenal hypofunc-tion during periods of major stress.

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