Genetic Considerations

Women with hereditary nonpolyposis colorectal cancer (HNPCC) have a risk of uterine cancer that is 50% higher than that of the general population. Uterine cancer is so common in this population that some families with HNPCC gene variants will have only cases of uterine cancer and no colon cancer. It is estimated that 1 in 10 women with uterine cancer may have a genetic predisposition. Genetic risk is higher if uterine cancer occurs before the age of 50, occurs along with another cancer, such as colon, ovarian, stomach or bile duct, occurs when there is a history of colon polyps before age 40, or when the patient has family members with other gastrointestinal (GI) cancers or polyps.

924 Uterine Cancer

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