Genetic Considerations

Several different genetic loci have been associated with an increased susceptibility to cerebral aneurysm with no phenotypic differences between familial and sporadic forms. In one study of familial inheritance patterns the autosomal recessive pattern was seen in slightly more than half the population and autosomal dominance was seen in just over one-third with about 5% showing incomplete penetrance. The autosomal dominantly transmitted disorder, polycystic kidney disease (ADPKD), has been associated with an increased incidence of intracerebral aneurysm.

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