Genetic Considerations

While both sporadic and familial forms of this disorder seem to exist, family history has been associated with an earlier onset, less invasiveness, and smaller lesions. A pattern of autosomal dominant transmission is seen in some populations. A person with one first-degree relative affected by melanoma has 2 to 3 times the risk of the general population and 6 times the risk if the relative was affected before age 50. The risk increases 13-fold if more than one first-degree relative is affected.

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