Genetic Considerations

While susceptibility to anaphylaxis is increased among those who have inherited sensitivity to antigens, the genetic component has not been well defined. Over 20 genes have been associated with the development of allergy and mutations and of these, many passed on in families. Family studies indicate that if both parents suffer from allergies, the allergy risk in their offspring is 80%. Implicated genes include the IL-4, IL-4 receptor, cytokine, INF7, p-adrenergic receptor, 5 lipoxygenase, PHF1, TARC, and leukotriene C4 synthetase genes.

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