Genetic Considerations

Mutation in the trypsinogen gene PRSS1 or mutations in the cystic fibrosis gene (CFTR) have been associated with heritable forms of pancreatitis. Since genetic testing for the PRSSI gene produces many false negatives, persons considered vulnerable are often instructed to make those lifestyle adaptations, such as avoiding alcohol and smoking and being vigilant about follow-up and screening, that will protect the pancreas. Mutations in

694 Pancreatitis other genes regulating pancreatic enzyme secretion have been seen in patients with chronic pancreatitis.

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