Hormone SIADH

Syndrome of inappropriate antidiuretic hormone (SIADH), a disorder of the posterior pituitary gland, is a condition of excessive release of antidiuretic hormone (ADH) that results in excessive water retention and hyponatremia. SIADH occurs when ADH secretion is activated by factors other than hyperosmolarity or hypovolemia. Excess ADH secretion increases renal tubular permeability and reabsorption of water into the circulation, resulting in excess extracellular fluid volume, reduced plasma osmolality, increased glomerular filtration rates, and decreased sodium levels. Without treatment, SIADH can lead to life-threatening complications. Water intoxication accompanied by sodium deficit may lead to free water movement into cerebral cells, which can cause cerebral edema and result in coma and even death.

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