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Nursing care varies, depending on the disease stage. Manage fever with cool sponge baths and limited bedding. Maintain a cool temperature in the environment if possible. Manage fatigue with promotion of rest and comfort. Ice bags are effective for headache. Arthralgia may require immobilization of the painful joint, warm moist applications, and other nonpharmacologic measures to control pain. Assist the patient with range-of-motion exercises and activities to strengthen muscles and joints, being careful not to overexert the patient.

Provide emotional support to patients who are experiencing memory loss and confusion. Determine the patient's chance for injury and plan accordingly by instituting safety measures. Frequently reorient the patient to her or his surroundings. Encourage the patient to share any concerns about her or his mental status. Explain the reason for the mental status changes to the patient and significant others, and answer any questions about the long-range complications of the disease.

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