Info

Test

Normal Result

Condition

Explanation

Monospot

Negative

Presence of heterophil antibodies

Identifies 90% of adult cases with Epstein-Barr virus; most common and specific test to confirm diagnosis

Complete blood

Red blood cells (RBCs):

Lymphocytosis with

Determines extent of

count with

4.0-5.5 million/pL; white

characteristic atypical

viral infection and

differential

blood cells: 4500-11,000/pL; hemoglobin (Hg): 12-18 g/dL; hematocrit (Hct): 37%-54%; reticulocyte count: 0.5%-2.5% of total RBCs; platelets: 150,000-400,000/pL; segmented neutrophils: 54%-62%; band neutrophils: 3%-5%; eosinophils: 1%-3%; basophils: <1%; monocytes: 3%-7%; lymphocytes: 25%-33%

lymphocytes in peripheral blood

immune dysfunction

IgM antibodies

Negative

Presence of specific antibodies for Epstein-Barr virus (EBV) antigens (viral capsid antigens, early antigens, or Epstein-Barr nuclear antigen)

Identifies presence of EBV

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