pg/mL indicates DIC

splitting fibrin as a result of plasmin during dissolution of fibrin clots. FDP quantifies amount of split products present in blood. In DIC, extensive breakdown of clots occurs.


150-360 mg/dL

Decreased <50 mg/dL

Decreased levels of fibrinogen (factor I) occur due to depletion of clotting factors

Partial thromboplastin

Varies by labora

Prolonged; may be

Indicates how long it takes for recal-

time (activated; APTT)

tory; generally 21-35 sec

prolonged >80 sec

cified, citrated plasma to clot after partial thromboplastin is added; screens for deficiencies in all factors except VII and XIII; factors are depleted, causing prolonged APTT

Platelet count



Platelets are consumed during clot formation

Prothrombin time (PT)

Varies by laboratory; generally 11-13 sec

Prolonged >15 sec

Prothrombin is a vitamin Independent glycoprotein that is necessary for firm clot formation; converts to throbin in clotting cascade. In DIC, clotting factors are depleted and PT is prolonged.

Other Tests: INR (

nternatlonal Normalized Ratio): Standardizes the PT ratio by allow-

ing laboratories to compare values with an international standard provided by the

World Health Organization. Formula is patients PT in seconds/mean normal PT in

seconds. In DIC, INR is elevated from a normal value of 1.3 to 1.6. Therapeutic range

for INR is 2.0 to 3.0 for people on warfarin. Factors: Decrease in factors II, V,

and VIII; prothrombin fragment 1 and 2 and fibrinopeptide A (through enzyme-

linked Immunosorbent assay, ELISA)

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