Radiation alone or systemic or regional chemotherapy

RADIATION THERAPY. Radiation therapy may be internal (radium applications to the cervix), external, and interstitial (by the use of cesium). Radiation cystitis, procitis, and fistula formation (vesicovaginal) are major complications. Radiation sickness (nausea, vomiting, diarrhea, malaise, fever) may be a result of a systemic reaction to the breakdown and reabsorption of cell proteins. Internal radiation results in some cramping because of dilation of the cervix and in a foul-smelling vaginal discharge because of cell destruction. The patient who receives intracav-ity radiation is placed on bedrest and is able only to roll from side to side so as not to dislodge the implant. Vaginal packing, a urinary catheter, and pretreatment enemas plus a low-residue diet are designed to keep healthy tissue from the implant. Smoking increases the side effects from radiation, and patients who smoke are encouraged to stop smoking.

Pharmacologic Highlights

Medication or Drug Class




Cisplatini; Paclitaxeli;

Depends on the


Used to treat or stabilize the

Ifosfamidei; Hydrox-

patient condition,

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