Pharmacologic Highlights

General Comments: Antibiotics worsen the symptoms of patients with IC by irritating

the bladder. The treatment of IC is controversial, and no single treatment is accepted

as best. Commonly used medications include anti-inflammatories, antispasmodics, tri

cyclic antidepressants, and antihistamines, which are used with varying success. Other

treatments include instillations of preparations such as sodium oxychlorosene (Clor-

pactin), silver nitrate, and dimethyl sulfoxide (DMSO) directly in the bladder to pro

mote healing and relief of pain. Sodium pentosan polysulfate (Elmiron) is used orally to

create a protective mucin layer in the bladder.

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