Pharmacologic Highlights

Medication or Drug Class

Dosage

Description

Rationale

Ganciclovir

5 mg/kg q 12 hr of IV for 1421 days, then 5 mg/kg q day for 7 days, then 1000 mg PO tid

Antiviral

Inhibits DNA production In CMV

Foscarnet

60 mg/kg q 8 hr or 90 mg/kg q 12 hr for 2-3 weeks, then 90-120 mg/kg per day of IV

Antiviral

Inhibits replication of virus

Other Drugs: Immunoglobulins may also be used as passive Immunization for the prevention of CMV disease.

Independent

Important priorities are to maintain an adequate level of functioning, prevent complications, support the recuperative process, and provide information about the disease process, prognosis, and treatment. Patients, and caregivers in the case of infants, need to be educated about decreasing the risk of spreading CMV infection. Secretions, particularly in infants, are apt to contain the virus.

Families of infants with CMV infection will need emotional support. Answer questions about CMV infection, symptoms, complications, and treatment.

Teach adult patients about the CMV infection, the need for adequate rest, exercise, good nutrition, and fluid intake.

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