Chronic fatigue immune dysfunction syndrome (CFIDS) is a unique, controversial, and poorly understood chronic disease that has a sudden onset in most cases. It is a multiple symptom disease that affects the immune and neurological systems and suggests chronic
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mononucleosis. Like many chronic illnesses, CFIDS is debilitating and is often accompanied by depression.
CFIDS has been mentioned throughout history but only recently has been defined for adults as a distinct disorder. It is characterized by chronic fatigue, lasting for at least 6 months and often much longer; it causes impaired overall physical and mental functioning. The Centers for Disease Control and Prevention (CDC) criteria have been formulated to standardize diagnosis and include: cognitive difficulties, pharyngitis, lymphadenopathy, muscle pain, joint pain, headache, sleep disturbance, poor sleep, and postexercise malaise.
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