C

197Cs—1982

Early 1980s Early 1980s

198Cs—199Cs

198Cs—199Cs

Discovery of an anticoagulant activity by Seegers et al. (Wayne State University)

Bovine protein C Lilly targeting Beckman et al. Methods identified, purified Stenflo et al. (University of Lund)

rhAPC as potential new therapy for diseases such as stroke/sepsis clone human protein C

discovered to make rhAPC, a very complex glycoprotein

Scientists conduct preclinical pharmacology toxicology testing of rhAPC

12/1994

1/1995

Mid 1990s

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