Contents

5.1 Introduction 97

5.2 Biochemical Aspects 98

5.3 Catalytic Mechanism 101

5.4 Determination of Activity 103

5.5 Therapeutic Applications 104

5.5.1.1 Rationale and Clinical Results 104

5.5.1.2 Adverse Effects, Interactions, and Pharmacokinetics 105

5.5.1.3 Formulation and Administration Aspects 106

5.5.1.4 Nonresponders and Inhibition of DNase I by Actin 106

5.5.2 DNase I in Non-CF Respiratory Diseases 107

5.5.3 DNase I in Systemic Lupus Erythematosus 108

5.5.4 DNase I in Wound Healing and Cancer 109

5.6 Production and Stability of rhDNase 1 109

5.7 Prospects 110

References 110

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