Human coagulation factor VII (FVIIa). FVIIa is a serine protease of 406 residues. The active two-chain enzyme is generated by specific cleavage after R152 . Posttranslational modifications of the FVII molecule include: (i) y-carboxylation of ten glutamic acid residues in the N-terminal part of the molecule; (ii) N-glycosylation of asparagine residues in positions 145 and 322; and (iii) O-glycosylation of S52 and S60. y : y-carboxyglutamic acid; *: glycosylation sites; activation site; O: catalytic site residues.
Was this article helpful?