Figure 112

Schematic diagram outlining (A) the genomic organization of the human F9 gene. The exons (a-h) and introns are labeled according to the scheme proposed in [9]. (B) FIX mRNA transcribed from F9. (C) The 461-aa precursor FIX protein, with its seven structural domains. (D) The 415-aa mature hFIX, found circulating in plasma, consists of five structural domains. (E) The 385-aa activated FIX (FIXa) contains an N-terminal light chain (composed of the Gla and EGF 1 and 2 domains), and is linked via a disulfide bond to the C-terminal heavy chain (containing the catalytic domain). See text for further details. The diagram is not drawn to scale.

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