Ancrod action on fibrinogen. FpA, fibrinopeptide A; FpB, fibrinopeptide B; XIIIa, blood factor XIII; RES, reticuloendothelial system. (Adapted from http://www.strokeonline.net/strok000.htm.)
fibrinogen concentration. By lowering the fibrinogen concentration, the enzyme acts as an anticoagulant and lowers plasma viscosity [75,78,80,81]. In addition, it stimulates the production of prostacyclin by endothelial cells, which inhibits platelet aggregation and formation of thrombi [82,83].
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