Fibrin displays binding sites for both tPA and plasminogen, facilitating activation of the fibrinolytic process directly at the clot surface.

Plasminogen and in consequence is only slowly inactivated by a2-antiplasmin. Such clot-bound plasmin displays an average half-life of approximately 1 min.

Overall, therefore, the thrombolytic system has evolved in a self-regulating fashion, which ensures efficient clot degradation while minimizing potential disruption of other elements of the hemostatic system.

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