Figure

Fibrin displays binding sites for both tPA and plasminogen, facilitating activation of the fibrinolytic process directly at the clot surface.

Plasminogen and in consequence is only slowly inactivated by a2-antiplasmin. Such clot-bound plasmin displays an average half-life of approximately 1 min.

Overall, therefore, the thrombolytic system has evolved in a self-regulating fashion, which ensures efficient clot degradation while minimizing potential disruption of other elements of the hemostatic system.

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