The three-dimensional structure of DNase I. p-Strands (capital letters) are represented by arrows and a-helices by cylinders. Two six-stranded p-pleated sheets consisting of strands E, F, C, A, P, N (sheet 1) and strands G, H, J, K, M, L (sheet 2) are packed against each other forming the core of the enzyme. The flexible loop region connects p-strands H and G. The carbohydrate side chain is attached to N18 at the beginning of helix I. The disulfide bridge between Cl73 and C209 is indicated. (From Suck, D., Oefner, C., and Kabsch, W., EMBO J, 3, 2423-2430, 1984. With permission.)

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