Glanzmanns Thrombasthenia

Patients with Glanzmann's thrombasthenia suffer from an abnormality in the glycoprotein (GP) GPIIb/IIIa complex, which results in a failure of the platelet aggregation at the site of injury. An International Registry on rFVIIa and congenital platelet disorders has been initiated [59] in which 11 surgical procedures and 55 bleeding episodes have been reported so far in 28 patients with Glanzmann's thrombasthenia. Data indicate that 9 out of 11 surgical procedures and 37 out of 55 bleeding episodes were treated successfully with rFVIIa.

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