Pharmacokinetics in Patients

Pharmacokinetic profiles have been studied in adult and pediatric hemophilia patients, as well as in adults with acquired FVII deficiency (i.e., healthy adult volunteers pretreated with acenocoumarol and patients with liver cirrhosis) [41-45]. The clearance and half-life values (range: 2.4 to 3.2 h) after bolus administration of rFVIIa were in the same range in the adult populations studied. However, pediatric patients with hemophilia have been reported to have a shorter half-life (1.3 h) and higher clearance values than the adults with hemophilia [42,44]. A clinical trial to evaluate this possible difference in half-life and clearance between adults and pediatric patients with hemophilia is in progress.

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