Potential N-linked glycosylation sites are indicated by bold type. The Ceredase sequence differs from that given above by the substitution of H495 (underlined) by arginine.
Differences in glycosylation can have a significant impact on the half-life, bioavailability, and biodistribution of proteins. Since both the placental and recombinant P-glucocerebro-sidase undergo the same carbohydrate-remodeling steps to produce mannose-terminated oligosaccharides, it was not expected that any major differences would arise in biological properties due to glycosylation differences. Nevertheless, a detailed comparison of the
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