Some of the Successes Achieved Using Rational Design to Improve Enzyme Thermostability


Amino Acid (aa) Changes and Rationale

Modified Characteristics


Aspergillus niger phytase

A 31-aa sequence from Aspergillus terreus phytase was

t1/2 at 49°C 308 min, wild type t1/2 at 49°C of 53 min



substituted by corresponding region from A. niger phytase

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