Table

Some of the Successes Achieved Using Rational Design to Improve Enzyme Thermostability

Enzyme

Amino Acid (aa) Changes and Rationale

Modified Characteristics

Ref.

Aspergillus niger phytase

A 31-aa sequence from Aspergillus terreus phytase was

t1/2 at 49°C 308 min, wild type t1/2 at 49°C of 53 min

[243]

(EC 3.1.3.8)

substituted by corresponding region from A. niger phytase

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